United States securities and exchange commission logo November 10, 2022 Douglas Love Chief Executive Officer Annexon, Inc. 1400 Sierra Point Parkway, Bldg C, Suite 200 Brisbane, CA 94005 Re: Annexon, Inc. Registration Statement on Form S-3 Filed November 4, 2022 File No. 333-268181 Dear Douglas Love: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Christine Westbrook at 202-551-5019 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Kathleen M. Wells, Esq.